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In adults with growth hormone receptor deficiency, eight weeks of rhIGF-1 therapy significantly increased whole-body protein synthesis, decreased protein oxidation and increased lean body mass while reducing fat mass, demonstrating enhanced muscle anabolism and nutrient utilization in humans
Transcriptional regulation of hepatic lipogenesis
Mechanisms: By enhancing pulsatile GH release and downstream IGF-1 signaling, Tesamorelin promotes lipolysis, especially in visceral fat depots, while supporting metabolic regulation and hepatic lipid metabolism
Int J Epidemiol (1989) 18(1):459
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