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Pre-filled pens for tirzepatide and semaglutide need refrigeration (28 C) until first use, and even after first use most stay stable at room temperature only for a limited window UK SmPCs allow up to 30 days at no more than 30 C for an in-use Mounjaro KwikPen, up to 56 days for an in-use Ozempic pen, and up to 28 days unrefrigerated for a Wegovy pre-filled pen

Fried foods, heavy cream sauces, fatty cuts of meat, and high-sugar foods can cause nausea or delayed gastric emptying symptoms in some patients

10.1007/s40618-017-0792-x 89 KimY.YooS.LimB.HongJ