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Reported side effects included: Nausea (most common, particularly during dose escalation) Vomiting Diarrhea Constipation Decreased appetite (this is also the mechanism, so it is both a side effect and the goal) Discontinuation due to side effects in the Phase 2 trial was around 16% in the highest dose group

While GLP-1 receptor agonist therapy leads to greater relative fat loss than lean mass loss, preserving muscle tissue requires adequate protein intake and resistance exercise during weight reduction