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Chronic stress reduces the appetite-suppressing effectiveness of GLP-1s, and perimenopausal estrogen decline dysregulates the HPA axis that cortisol and GLP-1 mechanisms share, raising baseline cortisol
Others are extrapolations from animal data that have not been studied in humans
In addition, researchers investigating MT-II's libido-boosting effects may administer 1-2mg/day up to four times a month, with at least 48 hours in between administrations [22, 19]
Therefore, while GLP-1RAs may represent a promising therapeutic option for managing psoriasis, further high-quality studies are needed to distinguish whether the therapeutic effects of GLP-1RAs originate from the direct regulation of immune cells or improvements in comorbidities such as obesity or diabetes
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