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The endogenous cleavage of the first six residues results in the biologically active peptide, which represents GLP-1 (736) amide
As shown in Scheme 10
2 Semaglutide converges these principles: the second residue is replaced by -aminoisobutyric acid (Aib) to avoid DPP-4 degradation, Lys 34 is replaced by Arg 34 , and a C18 fatty acid is linked to Lys 26 via a Glu-2xOEG spacer (Figure 1) providing higher affinity to albumin
Ngoi ra, glutathione khng c khuyn co cho ph n ang mang thai hoc cho con b
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