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Introduction Polycystic ovary syndrome (PCOS) is a common reproductive and endocrine disorder, affecting 5% to 20% of women of child-bearing age and accounting for approximately 75% of anovulatory infertility disorders

jamanetwork.com/journals/jamap : JAMA Psychiatry study highlights (semaglutide in schizophrenia spectrum disorders): Studied adults with schizophrenia spectrum disorders treated with clozapine or olanzapine, two antipsychotics strongly linked to weight gain and metabolic syndrome Participants were randomized to receive semaglutide (GLP-1 receptor agonist) vs placebo, in addition to usual psychiatric care Significant weight loss was observed in the semaglutide group compared with placebo Improved glycemic control including reductions in HbA1c and fasting glucose, even in early metabolic dysregulation Beneficial effects seen early, suggesting potential for prevention of diabetes rather than late treatment Semaglutide was generally well tolerated, with no worsening of psychotic symptoms Addresses a major unmet need, people with serious mental illness die earlier largely due to cardiometabolic disease Supports the role of GLP-1 receptor agonists as an adjunct treatment to mitigate antipsychotic-induced metabolic harm Bottom line: A promising strategy to reduce weight, diabetes risk, and long-term cardiovascular mortality in patients on high-risk antipsychotics

An increasing body of evidence suggests that GLP-1RAs may offer benefits beyond glycemic control, such as protective effects across cardiovascular, renal, hepatic, and endocrine systems

Ultrastructure of the taste bud of the human fungiform papilla