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In cultured tendon fibroblasts, Chang et al., J Appl Physiol 2011 reported that BPC-157 accelerated cell outgrowth from tendon explants, improved survival under oxidative (H 2 O 2 ) stress and increased fibroblast migration in a dose-dependent manner, effects the authors linked to the FAKpaxillin pathway
A 2019 FDA Drug Safety Communication specifically warned that gabapentinoids can cause serious breathing problems when combined with CNS depressants or in patients with underlying respiratory compromise [5]
McCord JM
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