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Gallbladder events rise modestly, especially with rapid loss. Less common signals include skin dysesthesia, which is now on the label, and a small thyroid-cancer association from two different instruments: a nested case-control study and an RCT meta-analysis, both on a small absolute event base. Depression and suicidality remain unproven

The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1