By slowing the rate at which the stomach empties its contents into the duodenum, GLP-1 agonists prolong the sensation of fullness, contribute to reduced caloric intake, and moderate postprandial glucose excursions
The estimated half-life is several hours based on animal data, though precise pharmacokinetic characterization remains incompletea limitation that underscores why human clinical trials would be essential to validate any therapeutic potential
AMPLITUDE-O Trial Investigators, Gerstein HC, Sattar N, Rosenstock J, Ramasundarahettige C, Pratley R, Lopes RD et al (2021) Cardiovascular and renal outcomes with efpeglenatide in Type 2 diabetes
The recommended amount of calories you intake daily will be based on your age, gender, and activity level, and it is important to follow this guideline, if you are not hungry then make sure you are taking a minimum of 1200 calories a day is important for maintaining your health