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Diffusion tensor imaging studies in migraine without aura have described thalamic microstructural changes between attacks in particular increased fractional anisotropy that varies with time since the last attack and appears to normalise during the attack itself [30] and correlated structuralfunctional alterations of the thalamo-cortical network [31]

Follow-up ICG demonstrated return of lymphatic pumping ( Figures 1 , 2 )

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Consequently, IGF-1 LR3 has improved biological potency and extended half-life