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In recent years, involvement of GSTs in different processes such as modulation of cell signaling kinases, formation and modulation of ion channels, oxidation-reduction reactions, and the post-translational glutathionylation of proteins have been outlined ( Different Classes and Catalytic Mechanism of GSTs Though the classification and nomenclature of GSTs in plants and animals are conundrum, however, they have been distinctly categorized into three families
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Regulation of glutathione in oxidative stress and cellular response mechanisms
Therefore, it is necessary to do a rigorous examination of the toxicity profile and biosafety risk assessment by studying the interaction of nanocarriers with the tissues and serum components before the clinical trials to encourage a greater number of subjects [374, 391]
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