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Understanding their unique benefits makes it easier to know when to supplement with one or both
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Recent work suggested that the reduction in both food intake and body weight observed in response to combined treatment with GLP-1RAs and PYY 3-36 results in synergistically-enhanced activation of discrete hypothalamic and brainstem circuits that regulate appetite, including the arcuate nucleus (ARC), the paraventricular nuclei of the hypothalamus (PVNs), the central nucleus of the amygdala (CeA), and the hindbrain (AP/NTS) 10,12,21,44
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