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The way I like to think about it is an evidence ladder, moving from mechanism to molecules to models to humans: At the time of writing, there are no peer-reviewed, controlled human data showing weight-loss or metabolic benefits for this product
By the studys end, people who stayed on the highest dose lost an average of 28.4% of their baseline weight, amounting to 71 pounds, while those on the lower dose lost an average of 26.4% body weight (the placebo group lost an average of 2.1%)
Furthermore, it was also responsible of in vitro endothelial cells conversion into a pro-inflammatory phenotype, characterized by increased expression of tissue factor, thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor [65]
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