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IDF Diabetes Atlas 9th Edition

Hypertensions pathogenesis has been linked to several variables, such as inflammation, renin-angiotensin-aldosterone system overexpression, sympathetic nervous system activation, and aberrant G protein-coupled receptor signaling, as shown in Figure 4 (129131)

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Meta-analyses of these and other studies have demonstrated: Reductions in total cholesterol typically in the range of 15% from baseline, varying by agent and population Decreases in LDL cholesterol ranging from 17%, generally more modest than dedicated lipid-lowering therapies Reductions in triglycerides of 515%, with greater effects often seen in those with higher baseline levels Variable effects on HDL cholesterol , with small increases (1-2%) or neutral effects reported The magnitude of lipid improvements appears to correlate with the degree of weight loss achieved, suggesting that metabolic benefits may be partially mediated through adiposity reduction