Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD
Notes from GLP-1 Match In our interactions with Hers, weve only ever engaged with customer service representatives, never a core leadership or medical team
In red are some additional amino acids, the tail from exendin in white, and the fatty acid sidechain, which all further improve the stability of the peptide
Remember that cysteine is one of the precursors to glutathione, so the idea is that ingesting NAC as a supplement indirectly increases your glutathione levels