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Some patients report that combining the two creates pronounced appetite suppression, which can be beneficial for weight loss but requires monitoring to ensure adequate nutrient intake

She said a combined approach with endoscopic sleeve gastroplasty could lead to an average weight loss of about 28% to 30% of total body weight, and with bariatric surgery, it could be from 25% to 40%

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So pharmaceutical companies are racing to make the next generation of these weight-loss treatmentsones that simultaneously target up to three food-related pathways in the brain