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Source: NEJM 2023 Safety profile: The most common adverse events were gastrointestinal (nausea 58%, diarrhea 39%, vomiting 32% in the 12 mg group)

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Maintenance strategies for semaglutide The STEP 4 trial demonstrated that patients who switched from semaglutide 2.4 mg to placebo regained an average of 11.6% of their body weight over the following 48 weeks, while those who continued semaglutide maintained their weight loss

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