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Male C57BL/6N mice were fed a 60% fat diet from 9 weeks of age until they became obese (body weight 40 g at 15-21-week old
Heavy alcohol use should be avoided, as it increases the risk of pancreatitis, a rare but serious side effect of tirzepatide
This review, will focus on the vital components that make up the BBB, dissect levels of disruption of the barrier, and discuss current drugs and therapeutics that maintain barrier integrity and the recent discoveries of effects microbial-derived metabolites have on BBB physiology
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