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GLS1 knockdown can disrupt the balance between ATP production and consumption, leading to increased synthesis and breakdown of creatine phosphate, a reserve of high-energy phosphates in the brain [79]

Nei soggetti diabetici pu essere necessaria una revisione della terapia, soprattutto se sono presenti insulina o sulfaniluree, per ridurre il rischio di ipoglicemia

Unexplained hypercobalaminemia, particularly levels above 1,000 pg/mL, has been associated with liver disease, kidney dysfunction, myeloproliferative disorders, and certain solid cancers in multiple large-scale studies

Appetite suppression can be more pronounced, so maintaining adequate protein and hydration is key