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Common side effects include: Cognitive slowing, including difficulties with memory, concentration, and word-finding Fatigue and drowsiness Dizziness and coordination problems Paraesthesia (tingling sensations, particularly in the hands and feet) Decreased appetite and weight loss Mood changes, including low mood, depression, and irritability More serious risks include: Metabolic acidosis topiramate inhibits carbonic anhydrase, which can reduce blood bicarbonate levels
In terms of incoherence, the design-by-treatment interaction model did not identify global inconsistency in the analyses for both primary outcomes (ESM Tables 4 and 5), while local inconsistency was also low
Side effects are rare but may include mild irritation or temporary dizziness
Because this technique allows for 100% absorption directly into the bodys tissues, it can be very effective for preventing or reversing a vitamin B12 deficiency
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