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Microarray gene expression profiling in colorectal (Hct116) and hepatocellular (Hepg2) carcinoma cell lines treated with melicope ptelefolia leaf extract reveals transcriptome profiles exhibiting anticancer activity
The C20 fatty diacid moiety enabling albumin binding extends the pharmacokinetic half-life to approximately 6-7 days, making once-weekly research dosing protocols practical
One of them, bardoxolone methyl (BARD, CDDO-Me, RTA402) is in the late stages of clinical trials for several conditions related to advanced chronic kidney disease including Alport syndrome and an autosomal dominant polycystic kidney disease and to pulmonary arterial hypertension (PAH)
Meister, A
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