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The real key is going to be side effects over time, if retatrutide is like other drugs in the class then the side effects should decrease with time, but unfortunately, we dont have that today, at this point I have some questions and minor concerns but without the data over time its hard to speculate about tolerability further beyond saying its similar to other drugs in the class

Any uninsured patient considering long-term GLP-1 therapy should undergo baseline metabolic and renal assessment

Persistent Gastrointestinal Issues: While improving, some digestive issues may still be present intermittently

Composition and functions of the gut microbiome in pediatric obesity: relationships with markers of insulin resistance