a - f , Treatment of C57BL/6 J DIO mice with once-daily subcutaneous (s.c.) injections of 900 nmol kg 1 MK-801 (n = 8 mice and n = 4 cages), 1800 nmol kg 1 MK-801 (n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 7 mice and n = 3 cages) over 7 days
Following that date, a $199 monthly cash price will apply to the 4 mg dose
Annual comprehensive reviews should assess whether current medication doses remain appropriate, whether nutritional status is adequate, and whether treatment goals need adjustment
Less common but more serious side effects include allergic reactions, sleep disturbances, joint pain, hyperactivity, carpal tunnel syndrome, diabetes risk, increased intracranial pressure, and the development of antibodies