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Results from slower gastric emptying and reduced food intake
GLP-1 drugs can reduce the need for CPAP machines as patients lose weight and improve their breathing
However, the SUSTAIN six trial evaluated semaglutide, a GLP-1 analog, in patients with type 2 diabetes and high cardiovascular risk and discovered that semaglutide was associated with a higher incidence of diabetic retinopathy complications compared to placebo, with a hazard ratio (HR) of 1.76, particularly in patients with pre-existing DR ( This seemingly controversial impact of GLP-1RAs on DR may be because most trials focused on microvascular and cardiovascular outcomes rather than DR
Boz explains that GLP-1 slows gastric emptying, which means food stays in the stomach longer and moves through the gut more slowly
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