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Retatrutide may be worth pursuing through clinical trial enrollment for patients with severe obesity (BMI above 40) who have not achieved adequate weight loss on existing therapies and who meet trial eligibility
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Berberine has poor bioavailability, with only 5 percent absorbed from the intestinal tract
Many patients on weight management programs or GLP-1 receptor agonists may develop B12 deficiency over time, leading to fatigue, weakness, and neuropathy
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