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In the SURMOUNT-1 trial (N=2,539) of tirzepatide, GI adverse events led to treatment discontinuation in only 4.3-7.1% of participants across dose groups 21, suggesting that most side effects including those downstream of GI symptoms like cramping are manageable without stopping therapy

doi: 10.1200/JCO.2005.01.072 274 RischinDPetersLJOSullivanBGiraltJFisherRYuenKet al

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