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Chronic fatigue and weakness that persists despite adequate sleep

Paracetamol may help manage mild to moderate body aches

For patients not responding adequately at 12 weeks on a stable maintenance dose, clinicians should verify proper administration technique, assess adherence patterns, and consider whether further dose escalation is appropriate and tolerable before concluding the medication is ineffective

The thalamus receives direct input from the trigeminovascular system during every migraine attack and may therefore be subject to greater cumulative oxidative stress than cortical regions less directly involved in pain processing