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It is produced by ligation (-glutamylcysteine synthetase, EC 6.3.2.2) of the gamma-carboxyl of glutamate (E) to the amino group of cysteine (C), then terminated by glutathione synthase (EC 6.3.2.3), with a conventional cysteine-glycine (C-G) peptide bond

Type 2 diabetes data were extracted based on 4 cohorts, which in total included 107,133 cases and 656,672 controls (Supplementary Table S2)