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The Top GLP-1 Skin Changes to Watch For: Facial Volume Loss ("Ozempic Face") Rapid weight loss can result in significant facial fat loss, leading to hollow cheeks, more prominent wrinkles, and sagging skin

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Gradual Introduction: Start with lower concentrations (e.g., 0.05% to 1%) and less frequent application (e.g., every other day) to allow the skin to acclimate, especially for sensitive skin types