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Moreira-Pinto B, Costa L, Felgueira E, Fonseca BM, Rebelo I

Another possibility is that obesity could lower serum vitamin B12 levels through decreased dietary intake or absorption, increased catabolism, and sequestration in adipose tissue, or changes in the gut microbiota profiles which could affect the metabolism of vitamin B12

doi: 10.1016/j.canlet.2011.12.012 49 LeeJYKimWKBaeKHLeeSCLeeEW

This correlates with the high NRF2 levels and increased fatty acid oxidation observed in quiescent versus activated adult stem cells and indicates that NRF2-dictated transcriptional events are critical drivers of increased reliance on mitochondrial function