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Research Handling Note: Allow sealed vials to reach ambient laboratory temperature before opening, to prevent condensation forming inside the vial

To evaluate the impact of these NRF2 target genes on TNBC prognosis, we plotted the significance (log 10 of p-values) of logrank tests for DEGs downregulated by Cyss depletion using the Kaplan-Meier plotter platform and based on relapse-free survival ( RFS) and distant metastasis-free survival (DMFS) as endpoints of patients with TNBC and ER+/PR+, ER+/PR, and ER/PR/Her+ non-TNBC [27]

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Interestingly, the GPX4 inhibitor RSL3 can impair the maturation and function of DCs in tumor suppression by activating PPARG/PPAR (peroxisome oroliferator activated receptor gamma)-dependent ferroptosis in DC2.4 cell line [195] (Fig