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Common side effects include Genital yeast infections (particularly in women) Urinary tract infections Nasopharyngitis back pain Serious side effects These are less common but require immediate medical attention: Ketoacidosis (a buildup of acids in the blood that can occur even when blood sugar is not very high) Severe kidney infections (pyelonephritis) Necrotizing fasciitis of the perineum (a rare but life-threatening soft tissue infection) Severe allergic reactions

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Both medications achieve clinically significant weight reduction, but tirzepatide demonstrates greater efficacy with 15-22% weight loss versus Qsymia's 6-10% in head-to-head comparisons

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