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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23

Although the number of events was small and the duration of follow-up short, patients randomised to oral semaglutide experienced a ~50% reduction in cardiovascular death (HR=0.49, 95% CI 0.27 to 0.92) and all-cause mortality (HR=0.51, 95% CI 0.31 to 0.84) (Figure 2)

What about patients who are using non insulin self injectable drugs like Ozempic or Mounjaro and the diagnosis is Obesity/Weight loss

rapid NAD+ infusions often cause flushing or dizziness, slow titration improves tolerance