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Several biomarkers deserve attention throughout the protocol
Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)
Key findings include: Glycemic Control: Once-daily Semaglutide pills resulted in a numerically greater reduction in blood sugar compared to the injection (1 mg), though the results were not statistically significant
Retatrutide is an investigational once-weekly injectable medication
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