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Melatonin decline represents both a biomarker and mediator of circadian aging

but note that postmarketing studies for several testosterone drug products have shown modest blood pressure increases, so blood pressure should be monitored 612 weeks after initiating TRT 325 Corrected and prevented anemia in men with and without baseline anemia, respectively 326 Increased libido and sexual activity and reduced other symptoms of hypogonadism, but did not relieve erectile dysfunction 327 Led to small improvements in mood and energy levels in those with and without significant depressive symptoms, but not those with persistent depressive disorder 328 Increased prostate-specific antigen (PSA) levels but did not affect risk of prostate cancer or events related to other prostate problems 240 Contrary to findings from some other trials, data from the TRAVERSE trial indicated TRT did not prevent progression to type 2 diabetes in those with pre-diabetes or improve blood glucose control in those with existing type 2 diabetes 329 and did not reduce fracture risk

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