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The gap between theoretical synergy and actual measurable outcomes comes down to three variables most protocols ignore: receptor saturation windows, NAD+ depletion kinetics, and the 46 hour offset that allows both compounds to exert their effects without interference

Someone with mild symptoms and a gut condition may still need injections, while someone with lower numbers and healthy digestion may respond well to oral B12

Providing anti-inflammatory effects Data showed that NNMT increases collagens and inflammatory molecules, which worsen inflammation

Key takeaway: May support the mobilization of stored fat for energy