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These individuals include: Allergy or hypersensitivity to GLP-1 medications Type 1 diabetes Pancreatitis Gastroparesis Medullary thyroid cancer Multiple endocrine neoplasia type 2 or family history of these conditions Pregnant, nursing, or trying to become pregnant Individuals with renal impairment Active eating disorder or history of disordered eating As always, the decision to use GLP-1s should be made in consultation with a healthcare professional who can assess an individual's medical history and overall health to determine if the medication is suitable for them

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GEP44 mediates insulin-independent glucose uptake in muscle via interactions with Y1-R GEP44 may also reduce serum glucose levels via direct interactions resulting in increased glucose uptake in muscle tissue

They are particularly suitable for those with a body mass index (BMI) of 35 kg/m or higher (with adjustment for ethnicity), or for those with a BMI below 35 kg/m where weight loss would benefit other significant obesity-related comorbidities