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Acetaminophen for the Patent Ductus Arteriosus: Has Safety Been Adequately Demonstrated

Although the drop in hepatic or renal GSH is the most toxicologically relevant interaction (see also below), plasma GSH, free cysteine (Nuttall et al., 2003) were significantly reduced after a single 2 g PAC administration or 14 days of therapeutic doses of PAC in human volunteers, respectively

The temperature was set at 310 K, using a thermostat damping of 0.1 ps 1 and the M-SHAKE algorithm 53 to constrain the bond lengths involving hydrogen atoms

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