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For biosynthesis of glutathione and homoglutathione share a common first reaction, i.e., the synthesis of -glutamylcysteine, but the chemical diversity results from altered specificity for the nucleophilic amino acid in the second reaction of the pathway

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To investigate synergism between PZQ or AS and the antioxidants, NTS were incubated with a constant dose ratio (1:1) of the highest concentration (100 M) of a combination of each anthelmintic and antioxidant (Additional file 1: Table S1)