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In this trial, at 60 weeks, the exenatide group showed a significant improvement in MDS-UPDRS Part III scores compared to the placebo group among the 62 recruited patients (80)
Together these data demonstrate that in DIO mice the GLP-1 peptide component of MEDI4166, despite being 52- and 37-fold less potent than Ab#2.1_EX4 at mouse GLP-1R in CHO transfected cells and MIN6 -cells respectively (Supplementary Table 9), resulted in more durable glucose control than the non-optimised fusion
If you are wondering when the "magic" happens, here is a realistic timeline of what occurs in your body from the first hour to the first year
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