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WHO recommends long-term treatment for obesity with GLP-1s in first-ever guidelines The guidelines highlight a shift to viewing obesity as a chronic illness, but safety evidence for GLP-1s remains limited
In such instances, investigators must assume a greater responsibility to independently assess the risk benefit ratio, and then accurately convey this to potential subjects to obtain true informed consent
Moreover, a decreased expression of the FABP1 and FOXA1 genes leads to decreased uptake of free fatty acids
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