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This difference was achieved without any change in food intake, suggesting the weight loss came from metabolic changes rather than appetite suppression

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Clinical studies have shown that some patients lose 5 to 15 percent of their body weight when GLP-1 medicines are combined with healthy lifestyle changes such as an improved diet and regular exercise

In contrast, people taking GLP-1 drugs did not have a reduced rate of hospitalization for heart failure compared with people who had diabetes but were not taking the drugs