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Mounjaro came first and is FDA-approved : To treat type 2 diabetes in adults by controlling their blood sugar levels Zepbound is FDA-approved : For chronic weight management in adults with obesity or overweight and a weight-related medical condition To treat obstructive sleep apnea in adults with obesity Prior to Zepbounds approval, healthcare providers may have been more likely to prescribe Mounjaro off-label for weight loss to patients with overweight or obesity who may not have had type 2 diabetes