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Intracellularly, the cytosolic concentrations of TRX family proteins are much lower compared to that of glutathione (GSH) but significant enough to provide additional reducing capacity to counter intracellular oxidative stress

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According to Gruchlik et al, GHK-Cu decreases TNF-alpha-dependent IL-6 secretion in fibroblasts, and is preferable for use on the skin to corticosteroids or non-steroidal anti-inflammatory drugs, which have greater side effects [9]

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