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An algorithm originally written to model sites of Cytochrome P450 metabolism (called XenoSite) finds clear patterns in molecular structure that identify sites of reactivity within reactive molecules with 90.8% accuracy and separate reactive and unreactive molecules with 80.6% accuracy

However, the rising prevalence of depression in the general population is coupled with an increasing number of patients who do not respond to antidepressant therapy, underlining the need to identify underlying factors to enable early detection and intervention, especially in high-risk groups [498]

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