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Muscle protein synthesis depends on two primary signals: Mechanical stimulus , usually provided through resistance training Amino acid availability , primarily from adequate dietary protein Resistance training activates the pathways responsible for muscle repair and growth, while dietary protein provides the amino acids required for rebuilding muscle tissue

This is why semaglutide is increasingly viewed as a long-term or potentially lifelong medication for obesity management, similar to how blood pressure or cholesterol medications are used chronically

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