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The lone Phase I trials silence is concerning
Abstract Hepatic steatosis is the main characteristic of some liver metabolism diseases
Analyses stratified by age at initiation and cumulative dose yielded consistent results, with all height differences falling below the prespecified threshold for clinical relevance
In cancer cells, increased ROS will oxidize the specific isoform of pyruvate kinase (PKM2), diverting glucose flux towards the PPP and generation of NADPH for GSH recycling
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