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Due to the challenge of the commitment to lifelong blood transfusion, the TWiTCH trial evaluated switching from transfusion to hydroxyurea for stroke prevention (Ware et al., 2016)

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A Look Ahead Given the studys limitations including its reliance on spontaneous reporting, lack of incidence rates, and inability to distinguish licensed from unlicensed compounders future investigations should include: Prospective safety registries for compounded GLP-1 RA users