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Stopping GLP-1 medications typically leads to weight regain, with most people regaining 50-70% of lost weight within 12 months as appetite and metabolic adaptations return

GLP-1 balance refers to the optimal production, secretion, and activity of glucagon-like peptide-1 (GLP-1), an incretin hormone produced primarily by enteroendocrine L-cells in the distal small intestine and colon

In addition, liraglutide inhibits the ability of alcohol to cause locomotor stimulation or to release dopamine in the NAc in male mice (Vallof et al., 2015)

The peptides and small molecules under development elicit weight loss by mimicking amylin, a naturally occurring hormone that plays a role in glucose regulation