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For Wegovy (once-weekly semaglutide) , recommendations depend on several factors including: Your individual risk profile Whether you're in the dose escalation phase The presence of significant gastrointestinal symptoms Local endoscopy unit policies Many patients can safely continue Wegovy before colonoscopy under moderate sedation

Weight comes back after stopping: in the STEP 1 extension, people regained about two-thirds of their lost weight within a year of stopping (Wilding and colleagues, Diabetes, Obesity and Metabolism , 2022)

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